Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | primary cultures of mature cortical neurons | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Mus musculus |
Tissue-type plasminogen activator | - |
Mus musculus |
tPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | despite its pro-fibrinolytic activity, tPA is a serine protease known to influence a number of physiological and pathological functions in the central nervous system. Accordingly, tPA mediates some of its functions in the central nervous system through N-methyl-D-aspartate receptors, low-density lipoprotein receptor-related protein, or annexin II. tPA can mediate proteolysis and subsequent delocalization of neuronal nitric oxide synthase, nNOS, thereby reducing endogenous neuronal nitric oxide release, independent of NMDA receptors, calpains, and low-density lipoprotein receptor-related proteins. tPA promotes proteolysis of nNOS through a plasmin-dependent mechanism, which is prevented in the presence of aprotinin and alpha2-antiplasmin, two blockers of the proteolytic activity of plasmin, overview | Mus musculus |